Figure 3.

PK metrics at steady state (left: C _max, middle: AUC _Plasma, right: AUC _Lung), including overall model imprecision after oral olodaterol inhalation. Presented metrics are normalized to the median PK metric of standard healthy volunteer (BSA: 1.89 m², non‐smoker, Caucasian). Points: normalized median PK metrics, lines: normalized 95% confidence intervals. AUC _Plasma: area under the plasma concentration–time profile at steady‐state (0–24 h after inhalation, n = 14 doses), AUC _Lung: Area under the unabsorbed amount–time profile at steady‐state (0–24 h after inhalation, n = 14), BSA: body surface area, “highest lung disposition scenario”: COPD, BSA 1.49 m², smoker, and Asian