Table 2.

Amikacin dosing recommendations in preterm and term neonates

Gestational age (weeks)	Post‐menstrual age (weeks)	Post‐natal age (days)	Weight (g)	Dose (mg kg –1 )	Dose interval (h)
Neofax 16
‐	≤ 29*	0–7	‐	18	48
‐		8–28	‐	15	36
‐		≥ 29	‐	15	24
* or significant asphyxia, PDA or treatment with indomethacin
‐	30–34	0–7	‐	18	36
‐		≥8	‐	15	24
‐	≥35	ALL	‐	15	24
Langhendries et al. 9
<28	‐	‐	‐	20	42
28–30	‐	‐	‐	20	36
31–33	‐	‐	‐	18.5	30
34–37	‐	‐	‐	17	30
>37	‐	‐	‐	15.5	24
6h prolongation of the dosing interval when ibuprofen is co‐administered
Sherwin et al. 3
‐	≤28	‐	‐	15	36
‐	29–36	‐	‐	14	24
‐	≥37	‐	‐	15	24
Does not apply to neonates of <3 days post‐natal age
De Cock RF et al. 6
‐	‐	<14	0–800	16	48
‐	‐	‐	800–1200	16	42
‐	‐	‐	1200–2000	15	36
‐	‐	‐	2000–2800	13	30
‐	‐	‐	≥2800	12	24
‐	‐	≥14	0–800	20	42
‐	‐	‐	800‐1200	20	36
‐	‐	‐	1200–2000	19	30
‐	‐	‐	2000–2800	18	24
‐	‐	‐	≥2800	17	20