Table 3.
Parameter (unit) | Estimate (RSE) [Shrinkage] | Bootstrap median [95% CI] |
---|---|---|
kin_0 (ng⋅ml−1 h−1) | 110 (13%) | 102 (73, 144) |
kout (h−1) * | 1.66 (−) | – |
β (l⋅μg−1) | 115 (22%) | 98 (47, 166) |
MTT (h) | 34.7 (12%) | 42 (30, 52) |
BSV | ||
BSV‐kin_0 (% CV) | 48.5 (22%) [8%] | 51.6 (11.8, 87.1) |
BSV‐β (% CV) | 73.9 (21%) [8%] | 83.5 (37.0, 144) |
BSV‐MTT (% CV) | 38.8 (34%) [8%] | 34.8 (2.4, 61.1) |
IOV | ||
IOV‐kin_0 (% CV) | 27.8 (17%) [27%] | 26.9 (18.4, 38.6) |
RUV | ||
RUV‐BNP (% CV) | 23.8 (15.2%) [23%] | 23.6 (17.0, 32.3) |
this parameter was fixed to literature value. β, slope factor as defined in Equation (3). BSV, between‐subject variability; CI, confidence interval; CV%, coefficient of variation; IOV, interoccasion variability; kin_0, baseline production rate of NT‐proBNP; kout, degradation rate constant of NT‐proBNP synthesis pathway; MTT, mean transit time; NT‐proBNP, N‐terminal pro B‐type natriuretic peptide; RUV, random unexplained variability;. Shrinkage of BSV, IOV and RUV is presented in square brackets.