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. 2017 Mar 6;7:43847. doi: 10.1038/srep43847

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(a) vir-1 gene (JAK/STAT) knockdown in Wolbachia-infected or tetracycline treated Aag2 cells. Gene expression was normalized to A. aegypti housekeeping gene rpS17. (b) DENV loads after knock down and challenge with DENV-2. Graphs show medians with interquartile ranges (n = 12 per treatment). Black columns depict scrambled controls. Significance is based on post-hoc comparisons following ANOVAs on logarithmic transformed data. ****p < 0.0001.