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. 2017 Mar 6;7:43849. doi: 10.1038/srep43849

Figure 2. MMP1 is an inhibitory factor of MDS cell proliferation.

Figure 2

(a) MMP1 mRNA expression in MDS-MSCs (n = 50; further classified as low-grade MDS (n = 29) and high-grade MDS (n = 21)) and normal control MSCs (n = 23) was measured by qPCR and compared with GAPDH. (b) MMP1 protein expression (54 kDa) in MDS-MSCs and normal control MSCs. (c)Addition of MMP1 inhibitor FN439 (5 μM) to normal control (NC) MSCs and SKM-1 co-culture increased the proportion of proliferating SKM-1 cells, as presented as flow cytometry plots (left) and a statistical figure (right). (Data represent the mean ± SEM from at least three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001).