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. 2017 Mar 6;7:43849. doi: 10.1038/srep43849

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The RNAi efficiency of MMP1 in MSCs was assayed by (a) qPCR and (b) western blotting before co-culture with MDS cells. MMP1 shRNA (both sh1 and sh2) decreased MMP1 expression of MSCs. (c) The percentage of MDS cells in S phase was evaluated by the EdU assay after co-culture with MMP1-KD MSCs (MMP1-sh1 MSCs and MMP1-sh2 MSCs) or negative MSCs (transfected with control lentiviruses) for 72 h. (d) The percentage of apoptotic MDS cells was assayed by Annexin V/PI dual staining after co-culture with MMP1-KD MSCs or negative MSCs for 72 h. (Data represent the mean ± SEM from at least three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001).