Figure 4. MMP1 affects proliferation and apoptosis of MDS cells through interaction with PAR1.

In the MDS-MSC and MDS cells co-culture system, 1 nM exogenous activated MMP1 was added with or without pre-administration of RWJ56110 (5 μM). The percentage of proliferating MDS cells and apoptotic MDS cells was assessed by the EdU assay (a) and Annexin V/PI dual staining (b). (Data represent the mean ± SEM from at least three independent experiments. *P < 0.05).