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Alternate conformation of Leu167 to Glu169. The involved residues and the ligand Cmpd-1 are shown in sticks. 2Fo–Fc map are shown in blue mesh contoured at 1.0 σ level. The major difference is with Phe168ECL2. The conformation that allow its aromatic ring to stack with Cmpd-1 is the dominant conformation with the occupancy of 0.7 (shown in green), and the occupancy of the other conformation is 0.3 (shown in gray).
