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The outward displacement of TM1 in A2AR–BRIL–Cmpd-1 structure is incompatible with the crystal packing of A2AR–BRIL–ZM241385. A2AR–BRIL–Cmpd-1 (green) is aligned with A2AR–BRIL–ZM241385 (orange). A symmetry molecule of A2AR–BRIL–ZM241385 (gray) that packs through their TM1 and TM7 shows steric conflicts with TM1 in A2AR–BRIL–Cmpd-1 and therefore prevents crystallization in the same lattice as A2AR–BRIL–ZM241385 in LCP. Residues with steric conflicts are shown in sticks.
