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. 2017 Jan 30;114(8):E1395–E1404. doi: 10.1073/pnas.1621188114

Fig. S8.

Fig. S8.

IRE1 inhibitors alter plaque composition and inflammation. Immunohistochemical and immunofluorescence analyses of proximal aorta sections obtained from ApoE−/− mice treated with STF-083010 or controls. In each case, representative images are shown in Left and Center, and the quantification of the data appears in Right. (A) Necrotic area was calculated (from indicated area) in the H&E-stained plaque sections. (Scale bar: 150 µm.) (B) Masson’s Trichrome collagen stain (collagen, blue; cytoplasm and muscle fibers, red; n = 5). (Scale bar: 200 µm.) (C) Fibrous cap thickness calculation from samples in A. (Scale bar: 100 µm.) (D) Anti–α-smooth muscle actin (VSMCs marker). (Scale bar: 200 µm.) (E) Anti-CD3 (T-cell marker). Arrowheads show CD3-positive cells (n = 5). Statistics are the same as in Fig. 1. (Scale bar: 200 µm.) ns, not significant. *P ≤ 0.05.