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. 2017 Feb 6;114(8):2012–2017. doi: 10.1073/pnas.1615413114

Fig. S3.

Fig. S3.

Exposure of mouse and human microglia to FTY720 does not dampen proinflammatory activation. Mouse and human microglia were activated and treated with FTY720 or vehicle. (A and B, Left) qPCR analysis of indicated genes expressed in activated murine (A) or human (B) microglia under FTY720 or vehicle treatment 24 h after activation. (A and B, Right) Measurement of NO content in supernatant of FTY720- or vehicle-treated microglia (n = 3 biological replicates). Data are mean ± SEM and representative of three independent experiments. (C and D) Assessment of neurotoxicity (C) and migration induction (D) in supernatants from activated murine microglia under treatment with FTY720 or vehicle. Data are mean ± SEM and representative of two independent experiments. P values were derived by Student’s t test (ns, not significant).