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Gata4 is required in the atrial septum progenitor of pSHF for atrial septation. (A and B) IHC staining of Gata4 in wild-type mouse embryos at E9.5. (C–R) Histology of Gata4 transgenic mouse embryo hearts at E13.5. Asterisks indicate missing structures of atrial septation. B, F–H, and N–R show the boxed areas in A, C–E, and I–M, respectively, at higher magnification. (Magnification: 40× in A, C–E, and I–M; 100× in B, F–H, and N–R.)
