Table S2.

Number of sequencing reads, mapped reads, and called peaks

Sample ID	Factor	Group	Total reads	Mapped reads	% mapped reads	Filtered reads	% filtered reads	No. peaks
wz154	ERα	Tamoxifen user	15,331,544	14,207,826	92.67	12,342,539	86.87	1,589
wz483	ERα	Tamoxifen user	18,754,169	17,283,692	92.16	1,5005,839	86.82	11,560
wz484	ERα	Tamoxifen user	19,287,976	18,138,678	94.04	15,509,489	85.51	2,355
wz489	ERα	Tamoxifen user	18,569,672	16,528,291	89.01	14,129,722	85.49	714
wz487	ERα	Tamoxifen user	23,924,152	15,740,024	65.79	13,543,920	86.05	100
WZ485	ERα	Tamoxifen user	32,296,216	26,465,862	81.95	22,901,235	86.53	504
wz439	ERα	Tamoxifen user	19,603,948	17,976,811	91.7	15,752,509	87.63	21,800
wz152	ERα	Tamoxifen user	14,930,170	12,101,826	81.06	10,116,835	83.6	27,915
wz170	ERα	Tamoxifen user	20,680,117	19,906,669	96.26	17,433,136	87.57	1,631
wz438	ERα	Tamoxifen user	15,611,205	14,725,046	94.32	12,681,132	86.12	123
wz490	ERα	Nonuser	20,899,419	18,917,776	90.52	16,402,313	86.7	455
wz488	ERα	Nonuser	19,444,847	18,274,374	93.98	160,19,957	87.66	26,714
wz486	ERα	Nonuser	30,403,020	18,373,438	60.43	15,788,112	85.93	19,055
wz470	ERα	Nonuser	32,936,222	29,363,575	89.15	24,987,722	85.1	1,312
wz503	ERα	Nonuser	14,880,365	13,780,675	92.61	11,885,851	86.25	391
wz504	ERα	Nonuser	22,411,738	21,007,108	93.73	18,174,472	86.52	3,223
wz984	H3K27ac	Tamoxifen user	23,175,814	22,016,196	95	20,519,524	93.2
wz985	H3K27ac	Tamoxifen user	22,900,854	22,227,909	97.06	20,621,089	92.77
wz565	H3K27ac	Tamoxifen user	41,850,397	40,395,208	96.52	36,913,144	91.38
wz990	H3K27ac	Tamoxifen user	29,613,393	28,327,999	95.66	26,416,294	93.25
wz991	H3K27ac	Tamoxifen user	24,977,421	23,739,843	95.05	21,921,727	92.34
wz992	H3K27ac	Tamoxifen user	31,443,859	29,791,112	94.74	27,645,455	92.8
wz1368	H3K27ac	Tamoxifen user	20,886,714	19,953,687	95.53	18,656,222	93.5
wz1045	H3K27ac	Tamoxifen user	25,954,861	24,892,026	95.91	23,468,485	94.28
wz981	H3K27ac	Tamoxifen user	26,601,717	25,544,357	96.03	23,749,000	92.97
Tam_5	H3K27ac	Nonuser	27,210,981	26,584,367	97.7	25,114,577	94.47
Tam_33	H3K27ac	Nonuser	28,796,446	27,937,355	97.02	26,006,528	93.09
Tam_38	H3K27ac	Nonuser	23,348,596	22,763,584	97.49	21,272,824	93.45
Tam_55	H3K27ac	Nonuser	29,667,180	28,638,563	96.53	26,233,736	91.6
Tam_102	H3K27ac	Nonuser	22,491,570	21,890,598	97.33	20,508,226	93.69
Tam_119	H3K27ac	Nonuser	22,791,103	22,188,485	97.36	20,885,046	94.13