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Diverged orthologous IDRs rescue fitness of wild-type S. cerevisiae IDR compared with 5A mutant. (A) High-throughput quantitative competition assay captures growth rate of cocultured cells over time. (B) Relative selection coefficients of 5A mutant and orthologous IDRs versus wild type. Error bars represent 1.96 SE; n = 2 for wild type, n = 4 for 5A, C. glabrata, and L. kluyveri IDRs.
