Skip to main content
. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Immunol Rev. 2017 Mar;276(1):26–39. doi: 10.1111/imr.12521

Figure 2. The third group of the B7-CD28 immune checkpoint family in the human cancer microenvironment.

Figure 2

B7-H3 dampens (red broken line) NK cells and T cells, and may reprogram metabolism in cancer cells. B7x inhibits T cells and potentiates (green broken line) myeloid derived suppressor cells (MDSC). HHLA2 restricts T cells and may promote angiogenesis through its receptor TMIGD2 on endothelial cells. Receptors for B7x and B7-H3 molecules have not yet been identified.