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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Clin Cancer Res. 2016 May 25;22(23):5805–5817. doi: 10.1158/1078-0432.CCR-15-3051

Figure 1. Activation of PI3K signaling in human and mouse PanNETs.

Figure 1

A. Representative IHC images of human pancreatic islet cells, and neuroendocrine islet cell tumors for pAKT (S473) (above), pPRAS40 (T246) (middle) and pS6 (S240/4) (below) stainings. For islet cell tumors, representative negative and positive stainings are shown. Black lines delimit the normal islet. Scale bar: 100 µm. B. Quantification for the pAKT (S473), pPRAS40 (T246) and pS6 (S240/4) staining in a cohort of 40 human pancreatic neuroendocrine tumors. Black lines delimit the normal islet. C. Representative images of the RIP1-Tag2 mouse model normal islet cells, encapsulated pancreatic tumor, and invasive carcinoma tumor stained with the PI3K pathway surrogates pAKT (S473), pPRAS40 (T246) and pS6 (S240/4). Dashed lines delimit the normal islet and the encapsulated tumor. Scale bar: 100 µm.