Fig. 8.

Therapeutic effect of rhu-αBC in WT mice after sciatic nerve crush injury. (A) Representative images of toluidine blue-stained, Epon-embedded sections and g-ratio analysis from WT animals treated with PBS (white bars) or rhu-αBC (black bars) at 28 d postcrush (n = 3–4 per group). (Magnification: 100×; scale bar: 10 µm.) (B) SFI examination and SFI difference in PBS- (white circles and bar) and rhu-αBC–treated (black circles and bar) injured WT mice before [naïve (N)] and 28 d after crush injury (representative of two experiments; n = 9–10 mice per group). All data represent mean ± SEM. *P < 0.05 (independent t test). (C) von Frey Hair test in PBS- (white circles and triangles) and rhu-αBC–treated (black circles and triangles) sham (S) and injured (I) WT animals tested before [naïve (N)] and after crush (I) (one experiment; n = 10 mice per group). Data were analyzed using two-way repeated measures ANOVA and represent mean ± SEM. *P < 0.05.