Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Feb 14;114(9):E1745–E1754. doi: 10.1073/pnas.1621314114

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 4. — CRYAB in astrocytes in MS lesions is preferentially phosphorylated at serine-59. (A and B) Immunohistochemical analysis of CRYAB in NAWM (A) and areas with active demyelination (B) demonstrates that CRYAB is expressed by astrocytes (arrows) and oligodendrocytes (arrowheads) in NAWM (A), and that expression of CRYAB is increased in astrocytes with reactive morphology in active demyelinating areas (B). (C–F) Analysis of CRYAB, phosphorylated at Ser-59 (C and D) and Ser-45 (E and F), in NAWM (C and E) and active demyelinating areas in MS tissue (D and F), reveals that phosphorylation of Ser-59 is not present in NAWM (C) and is dramatically increased in cells with reactive astrocyte morphology in active demyelinating lesions (D), whereas phosphorylation of Ser-45 is present in both NAWM (E) and active demyelinating areas (F). Nuclei were counterstained with hematoxylin. Insets depict magnified images of positive-staining astrocytes.