Table S1.

Voltage-dependent properties of WT and mutant hippocampal neurons

	CA1				CA3
	WT		N1768D/+		WT		N1768D/+
	Bipolar	Pyramidal	Bipolar	Pyramidal	Bipolar	Pyramidal	Bipolar	Pyramidal
n/N	11/5	11/4	11/8	9/7	10/9	8/5	9/5	8/6
Activation
Gmax, nS	5.03 ± 0.60	6.37 ± 1.08	5.02 ± 0.83	4.94 ± 0.66	3.34 ± 0.45	3.49 ± 0.57	3.24 ± 0.30	2.58 ± 0.10
k, mV	5.71 ± 0.73	6.94 ± 0.56	5.48 ± 0.46	6.76 ± 0.85	6.17 ± 0.62	6.72 ± 0.59	5.79 ± 0.60	5.35 ± 0.17*
V1/2, mV	−42.48 ± 1.83	−42.52 ± 2.24	−44.76 ± 1.61	−45.40 ± 1.60	−45.00 ± 2.29	−43.62 ± 2.32	−42.77 ± 1.91	−37.62 ± 1.72
Inactivation
k, mV	−6.90 ± 0.45	−6.97 ± 0.38	−7.69 ± 0.41	−7.31 ± 0.26	−6.10 ± 0.44	−6.87 ± 0.58	−7.26 ± 0.53	−6.83 ± 0.32
V1/2, mV	−70.94 ± 1.58	−72.80 ± 1.28	−71.55 ± 1.69	−68.93 ± 2.46	−65.50 ± 2.05	−65.32 ± 2.58	−68.68 ± 3.50	−66.03 ± 1.58
C (fraction)	0.08 ± 0.02	0.05 ± 0.01	0.06 ± 8.1e-3	0.07 ± 9.7e-3	0.03 ± 3.6e-3	0.02 ± 9.9e-3	0.07 ± 0.02*	0.08 ± 0.01*

N, number of animals; n, number of cells. *P < 0.05 compared with WT.