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Impaired affinity maturation in CXC12gagtm mice. (A) ELISA for high-affinity NP4-specific IgG1 in serum from control and CXC12gagtm mice at the indicated time points after immunization with NP35-CGG. (B) Ratio of NP4- and NP29-specific IgG1 titers. Data are from one representative experiment out of two and are presented as mean ± SEM from four control and five CXC12gagtm mice per time point. *P < 0.05; **P < 0.01 as determined by the two-way ANOVA test.
