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Q730E affects ERAP1 trimming activity and specificity. (A) ERAAP knockout fibroblasts were transfected with II/*002, Q730E, or II/*002-E320A ERAP1 together with either AIVMK-SHL8 (Top) or LEQLEK-SHL8 (Bottom) and assessed for their ability to stimulate SHL8-specific T-cell hybridoma B3Z. A representative experiment is shown. (B) The relative trimming activity of Q730E was compared to II/*002 for both AIVMK- and LEQLEK-SHL8 minigenes. Data was taken from at least six experiments.
