Table 3.
Arterial structure and function and hemodynamic changes in C57BL6 mice with or without BAPN treatment alone
| C56BL6 Mice | Aorta OD | Aortic Pressure | Left PA OD | mPAP | Left PA Collagen* | Z0 | ZC | PP | PWV | Fulton Index |
|---|---|---|---|---|---|---|---|---|---|---|
| Control | 543 ± 47 | 73 ± 6 | 510 ± 51 | 15 ± 3 | 62 ± 5% | 1.4 ± 0.3 | 0.29 ± 0.03 | 12 ± 2 | 3.1 ± 0.4 | 28 ± 1% |
| BAPN | 539 ± 19 | 75 ± 3 | 513 ± 4 | 13 ± 1 | 59 ± 8% | 1.0 ± 0.1 | 0.31 ± 0.06 | 15 ± 1 | 4.1 ± 0.8 | 29 ± 1% |
Values are means ± SE. There were no significant changes between mouse groups in large systemic and pulmonary artery geometry, left PA collagen concentration, or pulmonary vascular impedance. Aorta OD, aorta outer diameter (µm); BAPN, β-aminopropionitrile; left PA OD, left pulmonary artery outer diameter (µm); mPAP, mean pulmonary arterial pressure; Z0, total pulmonary vascular resistance (mmHg·min/ml); ZC, characteristic impedance (mmHg·min/ml); PP, pulse pressure (mmHg); PWV, pulse wave velocity (m/s). For aorta and left PA ODs, n = 4 per group. For all functional parameters including Fulton index, n = 6 for control and n = 4 for BAPN-treated group.
Measured as area percentage.