Fig. 4.
Wall shear stress (WSS)-diameter relationships in vessels isolated from rats fed a normal diet and rats in the HF-3D group. A: shear stress-induced vasodilation (SSID) of isolated plantaris muscle arteries was significantly enhanced in the HF-3D group compared with the normal-diet group (n = 8 in each group). Nω-nitro-l-arginine methyl ester (L-NAME, an inhibitor of NO synthase) had less inhibitory effects on SSID of rats fed a normal diet (B) than rats in the HF-3D group (C), resulting in elimination of their difference in the presence of L-NAME (D). *Significant difference between two curves. PD, passive diameter.