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. Author manuscript; available in PMC: 2017 Mar 6.
Published in final edited form as: Cell Syst. 2016 Nov 17;4(1):121–128.e4. doi: 10.1016/j.cels.2016.10.016

Figure 2. Visualization and Causal Modeling of Module 5.

Figure 2

(A) 309 probes contain a maximal membership in module 5. To examine the most important genes in the module, only those 47 probes (42 genes) that possess a module membership of 70% or greater (the “core” module) are shown. Diamonds indicate genes that have been previously implicated in heart disease. The color of the diamonds and circles indicate GO category membership, with blue indicating glycoprotein, red indicating signaling, green indicating extracellular region, and gray indicating no significant GO category membership.

(B) A schematic depicting the way in which the NEO algorithm uses genetic markers (indicated with an S) as anchors to infer directionality between two genes (indicated with an A and B).

(C) Module 5 after NEO. 44 probes of the module, representing 93.6% of the core module, showed at least one edge with significant inferred directionality. Circles indicate the nodes, while arrows indicate the inferred directionality by NEO between two nodes. Node color indicates the percentage of edges with inferred directions to or from the node, with green indicating 75% or greater inferred edges originating from the node, yellow indicating a roughly equal percentage of edges originating from and traveling to the node, and red indicating that 75% or greater of the edges originating from another node.