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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2016 Nov 15;9(1):10.1002/wsbm.1365. doi: 10.1002/wsbm.1365

Fig 1. Force balancing models of cell migration.

Fig 1

(A) A force balancing model of individual cell migration. (B) The later experimental validation (left) is consistent with the computational predictions (right), which successfully predicted the cell migration speed dependence on both the integrin concentration and the matrix stiffness. Iamges are obtained from Zaman et al.10 (Copyright (2006) National Academy of Sciences)(C) A force balancing model of collective monolayer cell migration. (D) This model successfully explained the mechanical wave-like cell migration and stress patterns, which are due to the reinforcement and fluidization of cytoskeleton. The experimental measurement is on the left and the numerical simulation is on the right using the force balancing model. Images are obtained from Serra-Picamal et al.34 (Adapted by permission from Macmillan Publishers Ltd: Nat. Phys. (Ref 34), copyright (2012))