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. Author manuscript; available in PMC: 2018 Mar 3.
Published in final edited form as: Circ Res. 2017 Mar 3;120(5):781–783. doi: 10.1161/CIRCRESAHA.116.310007

TABLE 1.

Functional Effects of PLN Partners

PLN Partners Effects
SERCA2a PLN Inhibits SERCA2a and Contractility
HAX-1 ↑ PLN inhibition
HAX-1 / Hsp90 ↑↑ PLN inhibition
Gm / PP1 Dephosphorylates PLN; ↑ PLN inhibition
Gm / PP1 / I-1 or Hsp20 Inhibits PP1; ↓ PLN inhibition
AKAP / PKA ↑ P-PLN (S16); ↓ PLN inhibition
CAMKII ↑ P-PLN (T17); ↓ PLN inhibition

Gm: muscle glycogen targeting subunit of PP1; PP1: protein phosphatase 1; P-PLN: phosphorylated PLN; AKAP: protein kinase A anchoring protein (AKAP7δ/γ; AKAP15; AKAP18 δ); I-1: Inhibitor 1 of PP1