Table 2.
Multivariable Cox regression analysis of GFR by 24-hour urine collection, eGFR-urea,creat, and urine volume for all-cause mortality (n=1946)
| Variable | HR (95% CI) | |||
|---|---|---|---|---|
| Base modela | Model 1b | Model 2c | Model 3d | |
| Age, yr | 1.04 (1.03 to 1.06) | 1.04 (1.03 to 1.06) | 1.04 (1.03 to 1.06) | 1.04 (1.03 to 1.06) |
| Women (versus men) | 0.90 (0.69 to 1.17) | 0.88 (0.68 to 1.14) | 0.91 (0.70 to 1.19) | 0.89 (0.69 to 1.16) |
| PD (versus HD) | 1.15 (0.90 to 1.45) | 1.27 (0.98 to 1.63) | 1.16 (0.91 to 1.47) | 1.15 (0.91 to 1.46) |
| Dialysis vintage, mo | 1.00 (1.00 to 1.01) | 1.00 (1.00 to 1.00) | 1.00 (1.00 to 1.06) | 1.00 (1.00 to 1.01) |
| Modified CCI (per 1) | 1.21 (1.15 to 1.27) | 1.21 (1.16 to 1.28) | 1.21 (1.15 to 1.28) | 1.21 (1.15 to 1.28) |
| Smoker (versus nonsmoker) | 1.09 (0.84 to 1.42) | 1.08 (0.83 to 1.40) | 1.10 (0.85 to 1.42) | 1.09 (0.84 to 1.41) |
| Albumin, per mg/dL | 0.61 (0.51 to 0.74) | 0.60 (0.49 to 0.72) | 0.61 (0.50 to 0.73) | 0.61 (0.50 to 0.74) |
| GFR-24U, per ml/min per 1.73 m2 | — | 0.98 (0.95 to 0.99) | — | — |
| eGFR-urea,creat, per ml/min per 1.73 m2 | — | — | 0.99 (0.95 to 1.03) | — |
| UV, per 0.1 L/d | — | — | — | 0.96 (0.94 to 0.98) |
HR, hazard ratio; 95% CI, 95% confidence interval; PD, peritoneal dialysis; HD, hemodialysis; CCI, Charlson comorbidity index; GFR-24U, GFR by 24-hour urine collection; eGFR-urea,creat, estimated GFR calculated from the serum urea and creatinine concentrations; UV, urine volume.
a
Base model: adjusted for age, sex, dialysis modality, dialysis vintage, modified CCI, smoking status, and serum albumin concentrations.
b
Model 1: Base model and GFR-24U.
c
Model 2: Base model and eGFR-urea,creat.
d
Model 3: Base model and UV.