Table 3.
Multivariable Cox regression analysis of GFR by 24-hour urine collection, eGFR β2-microglobulin, and urine volume for all-cause mortality (n=1640)
| Variable | HR (95% CI) | |||
|---|---|---|---|---|
| Base modela | Model 1b | Model 2c | Model 3d | |
| Age, yr | 1.05 (1.04 to 1.06) | 1.05 (1.04 to 1.06) | 1.05 (1.04 to 1.06) | 1.05 (1.04 to 1.06) |
| Women (versus men) | 0.88 (0.66 to 1.18) | 0.86 (0.64 to 1.15) | 0.85 (0.63 to 1.13) | 0.84 (0.63 to 1.13) |
| PD (versus HD) | 1.21 (0.94 to 1.56) | 1.35 (1.93 to 1.76) | 1.36 (1.04 to 1.78) | 1.44 (1.11 to 1.89) |
| Dialysis vintage, mo | 1.00 (1.00 to 1.01) | 1.00 (1.00 to 1.01) | 1.00 (1.00 to 1.01) | 1.00 (1.00 to 1.00) |
| Modified CCI (per 1) | 1.20 (1.14 to 1.27) | 1.21 (1.14 to 1.28) | 1.21 (1.14 to 1.28) | 1.20 (1.13 to 1.26) |
| Smoker (versus nonsmoker) | 1.08 (0.81 to 1.45) | 1.06 (0.80 to 1.42) | 1.08 (0.81 to 1.44) | 1.05 (0.79 to 1.40) |
| Albumin, per mg/dL | 0.65 (0.53 to 0.80) | 0.63 (0.51 to 0.78) | 0.63 (0.51 to 0.78) | 0.62 (0.50 to 0.76) |
| GFR-24U, per ml/min per 1.73 m2 | 0.97 (0.95 to 0.99) | — | — | |
| eGFR B2M, per ml/min per 1.73 m2 | 0.98 (0.96 to 0.99) | — | ||
| UV, per 0.1 L/d | 0.96 (0.94 to 0.98) | |||
These analyses were performed in 1640 patients who had available B2M data. HR, hazard ratio; 95% CI, 95% confidence interval; PD, peritoneal dialysis; HD, hemodialysis; CCI, Charlson comorbidity index; GFR-24U, GFR by 24-hour urine collection; B2M, β2-microglobulin; UV, urine volume.
a
Base model: adjusted for age, sex, dialysis modality, dialysis vintage, modified CCI, smoking status, and serum albumin concentrations.
b
Model 1: Base model and GFR-24U.
c
Model 2: Base model and eGFR B2M.
d
Model 3: Base model and UV.