Table 4.
Univariate and multivariate competing risks regressions for conversion to active status among patients designated inactive due to incomplete candidate evaluation
| Variable (Reference) and Level | Univariate | Multivariatea | ||
|---|---|---|---|---|
| Subhazard Ratio (95% CI) | P Value | Subhazard Ratio (95% CI) | P Value | |
| Sex (women) | ||||
| Men | 1.04 (1.02 to 1.07) | <0.001 | 1.08 (1.06 to 1.11) | <0.001 |
| Age (<40), yr | ||||
| 40–49 | 0.88 (0.86 to 0.92) | <0.001 | 0.89 (0.86 to 0.92) | <0.001 |
| 50–59 | 0.82 (0.80 to 0.85) | <0.001 | 0.83 (0.80 to 0.86) | <0.001 |
| ≥60 | 0.80 (0.78 to 0.83) | <0.001 | 0.81 (0.78 to 0.84) | <0.001 |
| Race/ethnicity, % (white) | ||||
| Black | 0.80 (0.77 to 0.82) | <0.001 | 0.86 (0.84 to 0.89) | <0.001 |
| Hispanic | 0.72 (0.69 to 0.75) | <0.001 | 0.90 (0.86 to 0.94) | <0.001 |
| Asian | 0.91 (0.86 to 0.96) | 0.001 | 0.98 (0.93 to 1.03) | 0.37 |
| Other | 0.72 (0.65 to 0.80) | <0.001 | 0.81 (0.73 to 0.90) | <0.001 |
| Blood type (O) | ||||
| A | 1.08 (1.05 to 1.11) | <0.001 | 1.04 (1.02 to 1.07) | 0.001 |
| B | 1.00 (0.96 to 1.03) | 0.80 | 1.01 (0.98 to 1.04) | 0.59 |
| AB | 1.11 (1.05 to 1.18) | <0.001 | 1.08 (1.03 to 1.15) | <0.01 |
| BMI at listing (<30 kg/m2), % | ||||
| 30–34.9 | 0.99 (0.96 to 1.02) | 0.41 | 1.02 (0.99 to 1.04) | 0.28 |
| 35–39.9 | 0.78 (0.75 to 0.81) | <0.001 | 0.79 (0.76 to 0.82) | <0.001 |
| 40–44.9 | 0.56 (0.52 to 0.61) | <0.001 | 0.55 (0.51 to 0.60) | <0.001 |
| 45–64.9 | 0.55 (0.48 to 0.64) | <0.001 | 0.55 (0.48 to 0.64) | <0.001 |
| PRA (<80%) | ||||
| ≥80% | 1.23 (1.20 to 1.27) | <0.001 | 1.26 (1.22 to 1.31) | <0.001 |
| Dialysis at listing (no) | ||||
| Yes | 0.85 (0.83 to 0.87) | <0.001 | 0.96 (0.93 to 0.99) | 0.003 |
| Education (college or above) | ||||
| Less than high school | 0.72 (0.69 to 0.76) | <0.001 | 0.89 (0.84 to 0.93) | <0.001 |
| High school or GED | 0.86 (0.83 to 0.88) | <0.001 | 0.90 (0.88 to 0.93) | <0.001 |
| Unknown | 0.83 (0.79 to 0.87) | <0.001 | 0.88 (0.84 to 0.92) | <0.001 |
| Primary cause of ESRD (diabetes) | ||||
| Hypertension | 1.12 (1.08 to 1.16) | <0.001 | 1.12 (1.09 to 1.16) | <0.001 |
| GN | 1.49 (1.44 to 1.55) | <0.001 | 1.32 (1.27 to 1.37) | <0.001 |
| Polycystic kidney | 1.59 (1.51 to 1.66) | <0.001 | 1.37 (1.30 to 1.43) | <0.001 |
| Other | 1.24 (1.20 to 1.28) | <0.001 | 1.11 (1.07 to 1.15) | <0.001 |
| Insurance type (private) | ||||
| Public | 0.77 (0.76 to 0.79) | <0.001 | 0.82 (0.80 to 0.85) | <0.001 |
| Previous transplant (no) | ||||
| Yes | 1.11 (1.08 to 1.15) | <0.001 | 0.91 (0.88 to 0.95) | <0.001 |
| Zip code–level characteristic | ||||
| Linguistically isolated households (<1%), % | ||||
| 1–4.9 | 0.93 (0.88 to 0.98) | <0.01 | 0.94 (0.89 to 0.98) | <0.01 |
| 5–9.9 | 0.91 (0.86 to 0.96) | 0.001 | 0.91 (0.86 to 0.95) | <0.001 |
| 10–19.9 | 0.80 (0.75 to 0.86) | <0.001 | 0.84 (0.79 to 0.89) | <0.001 |
| ≥20 | 0.70 (0.66 to 0.75) | <0.001 | 0.79 (0.74 to 0.85) | <0.001 |
| Households below poverty level (<5%), % | ||||
| 5–9.9 | 0.93 (0.90 to 0.97) | 0.001 | 1.01 (0.98 to 1.06) | 0.46 |
| 10–19.9 | 0.85 (0.81 to 0.88) | <0.001 | 1.02 (0.97 to 1.07) | 0.40 |
| ≥20 | 0.73 (0.70 to 0.76) | <0.001 | 0.99 (0.93 to 1.05) | 0.68 |
| Zip code households with less than high school education (<5%), % | ||||
| 5–9.9 | 0.89 (0.86 to 0.92) | <0.001 | 0.96 (0.93 to 1.00) | 0.08 |
| 10–19.9 | 0.80 (0.77 to 0.83) | <0.001 | 0.94 (0.89 to 0.99) | 0.03 |
| ≥20 | 0.69 (0.65 to 0.73) | <0.001 | 0.96 (0.87 to 1.05) | 0.36 |
95% CI, 95% confidence interval; BMI, body mass index; PRA, panel reactive antibody; GED, General Education Diploma.
a
Multivariate model 1 was adjusted for sex, age, race/ethnicity, blood type, BMI at listing, percentage of PRAs (<80% versus ≥80%), dialysis status at waitlist registration, highest education level achieved, primary cause of ESRD, primary insurance type, history of previous transplant, and percentages of linguistically isolated households, households below poverty level, and households with less than high school education within the candidate’s zip code of residence.