Skip to main content
. 2017 Feb 17;12(3):493–501. doi: 10.2215/CJN.07600716

Table 1.

Baseline characteristics according to trial group assignment

Variable Donors Assigned to Treatment Donors Assigned to Controls P Value
Dopamine Not Given Or Prematurely Terminated Dopamine Administered per Protocol
N n=21 n=103 n=140
Mean age (SD), yr 51.2 (11.3) 50.6 (15.2) 50.8 (14.8) 0.99
Women, n (%) 11 (52.4) 50 (48.5) 76 (54.3) 0.70
Mean serum-creatinine (SD), mg/dla 0.72 (0.19) 0.86 (0.31) 0.84 (0.26) 0.12
Mean systolic BP (SD), mmHga 131 (19) 133 (19) 128 (17) 0.13
Mean diastolic BP (SD), mmHga 75 (13) 71 (11) 71 (11) 0.26
Mean urine production last 24 h (SD), ml 4880 (2880) 4900 (2410) 4760 (2460) 0.90
Mean urine production last h (SD), ml 205 (122) 204 (141) 179 (107) 0.26
Mean Kidney Donor Profile Index (SD), % 51 (23) 54 (28) 53 (26) 0.91
Median time from admission on ICU to brain death confirmation (IQR), d 3 (1–4) 3 (1–5) 3 (2–8) 0.18
Median time from brain death confirmation to start of cold perfusion (IQR), h 9.3 (7.9–10.5) 9.8 (7.8–11.9) 9.0 (6.8–11.9) 0.32
Median time from brain death confirmation to initiation of the dopamine infusion (IQR), h 2.6 (1.7–4.2)b 3.0 (0.8–5.6) n.e. 0.53
Median duration of the dopamine infusion (IQR), h 0.8 (0.7–2.0) 6.2 (4.9–8.3) 0
Median time from cessation of dopamine to initiation of perfusion (IQR), h 3.8 (2.1–6.2)b 0 n.e.
Recipients and transplant characteristics
 N n=40 n=187 n=260
 Mean age (SD), yr 49.8 (11.9) 53.4 (12.8) 52.0 (12.4) 0.18
 Women, n (%) 15 (37.5) 79 (42.3) 96 (36.9) 0.54
 Mean weight (SD), kg 74.8 (14.4) 75.0 (15.3) 73.0 (12.9) 0.30
 Diabetes, n (%) 6 (15.0) 30 (16.0) 36 (13.9) 0.81
 Previous transplant, n (%) 3 (7.5) 24 (12.8) 47 (18.1) 0.12
 Mean cold ischemic time (SD), h 14.7 (5.3) 13.4 (5.5) 14.2 (5.2) 0.19
 Mean antigen mismatches A, B, and DR (SD), n 2.8 (1.7) 2.8 (1.6) 2.8 (1.6) 0.95
 Panel reactive antibody >5%, n (%) 3 (7.5) 21 (11.2) 34 (13.1) 0.64

The intervention group is subdivided in donors and transplants treated per protocol and those prematurely withdrawn from the infusion for side effects or not given dopamine despite randomization to treatment. ICU, intensive care unit; IQR, interquartile range; n.e., not estimable; —, not applicable.

a

Last assessment before organ procurement.

b

Not estimable in five donors not given dopamine.