Table 1.

Summary of transcriptome comparison of S. pneumoniae D39 wild-type grown in CDM with and without 5 mM aspirin.

D39 taga	Functionb	Ratioc
spd_0775	Hypothetical protein	2.7
spd_1932	Maltodextrin phosphorylase, MalP	2.6
spd_1933	4-alpha-Glucanotransferase, MalQ	2.3
spd_1834	Alcohol dehydrogenase, iron-containing	2.3
spd_0459	Heat shock protein, GrpE	2.2
spd_0460	Chaperone protein, DnaK	2.1
spd_1636	Alcohol dehydrogenase, zinc-containing	2.1
spd_2002	Undecaprenol-phosphate-poly (glycerophosphate subunit) D-alanine transfer protein, DltD	1.9
spd_0868	Protease maturation protein, putative	1.9
spd_0420	Formate acetyltransferase, PflB	1.8
spd_1006	Glucose-1-phosphate adenylyltransferase, GlgC	1.8
spd_1007	Glucose-1-phosphate adenylyltransferase, GlgD	1.8
spd_0927	Neopullulanase, NplT	1.8
spd_0379	Transcriptional regulator, marr family protein	− 1.8
spd_0401	Ribosomal protein L28	− 1.8
spd_0652	Branched-chain amino acid ABC transporter, amino acid-binding protein, LivJ	− 1.8
spd_1726	Pneumolysin, Ply	− 1.8
spd_0192	Ribosomal protein S10	− 1.8
spd_0380	3-Oxoacyl-(acyl-carrier-protein) synthase III, FabH	− 1.8
spd_0409	Threonine dehydratase, IlvA	− 1.8
spd_1158	NADP-specific glutamate dehydrogenase, GdhA	− 1.9
spd_0646	Hypothetical protein	− 1.9
spd_0382	trans-2-Enoyl-ACP reductase II, FabK	− 1.9
spd_1727	Hypothetical protein	− 1.9
spd_0674	Ribosomal protein S16	− 1.9
spd_0385	3-Oxoacyl-[acyl-carrier-protein] synthase II, FabF	− 1.9
spd_0161	Hypothetical protein	− 1.9
spd_0448	Glutamine synthetase, type I, GlnA	− 1.9
spd_1370	Ribosomal protein S6	− 2
spd_1525	ABC transporter, ATP-binding protein	− 2
spd_0383	Malonyl coa-acyl carrier protein transacylase, FabD	− 2
spd_0219	Ribosomal protein L17	− 2.1
spd_1964	Ribosomal protein L33	− 2.2
spd_0334	Oligopeptide ABC transporter, oligopeptide-binding protein, AliA	− 2.3
spd_0447	Transcriptional regulator, MerR family protein	− 2.3
spd_0251	Ribosomal protein S12	− 2.3
spd_0387	Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabZ	− 2.3
spd_0388	Acetyl-coa carboxylase, biotin carboxylase, AccC	− 2.3
spd_0404	Acetolactate synthase, large subunit, biosynthetic type, IlvB	− 2.3
spd_0390	Acetyl-coa carboxylase, carboxyl transferase, alpha subunit, AccA	− 2.3
spd_0405	Acetolactate synthase, small subunit, IlvN	− 2.4
spd_0408	Hypothetical protein	− 2.4
spd_0407	Hypothetical protein	− 2.4
spd_1963	Ribosomal protein L32	− 2.4
spd_0389	Acetyl-coa carboxylase, carboxyl transferase, beta subunit, AccD	− 2.4
spd_0274	Ribosomal protein L13	− 2.5
spd_1524	Transcriptional regulator, GntR family protein	− 2.6
spd_0386	Acetyl-coa carboxylase, biotin carboxyl carrier protein, AccB	− 2.8
spd_0406	Ketol-acid reductoisomerase, IlvC	− 2.8
spd_1526	Hypothetical protein	− 2.9
spd_0275	Ribosomal protein S9	− 3

^aGene numbers refer to D39 locus tags.

^bD39 annotation [12].

^cRatio (> 1.8 or <− 1.8) represents the fold increase/decrease in the expression of genes in the presence of aspirin in CDM.