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VPO1 regulates eNOS expression through PRMT1/ADMA pathway. HUVECs were treated with AngⅡ for 24 h after transfected with siVPO1. (A) VPO1 gene knockdown reversed AngⅡ induced decrease of cGMP generation. (B–C) the eNOS protein and mRNA expression. (D–E) the PRMT1 protein and mRNA expression. (F) AMDA was measured by HPLC(n=3 per group) (**P<0.01) vs control group. (##P<0.01) vs AngⅡ group, (n=3 per group).
