Fig. 4.

Survival of Farber disease mice receiving repeat injections of rhAC. Approximately 3-week-old Farber disease mice received once weekly i.p. injections of purified rhAC at doses of 1 mg/kg, 3 mg/kg and 10 mg/kg (n = 9-56/dose). Mice were euthanized when they lost > 10% body weight within a one week period. Kaplan-Meir plots were used to indicate survival probability. “0” indicates Farber disease mice receiving once weekly injections of PBS.