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. 2017 Feb 13;7:85–96. doi: 10.1016/j.bbacli.2017.02.001

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 8 — Histology in liver and spleen sections from Farber disease mice receiving repeat injections of rhAC. Approximately 3-week-old Farber disease mice received once weekly i.p. injections of purified rhAC at doses of 1 mg/kg, 3 mg/kg and 10 mg/kg (n = 4–10/dose). Mice were euthanized when they lost > 10% body weight within a one week period. Livers (A) and spleens (B) were fixed in formalin, sectioned and subjected to H&E staining. “0” indicates Farber disease mice receiving once weekly injections of PBS. WT indicates age-matched wild-type mice. Representative sections are shown from mice in each dose group. Magnification = 20 ×.

Fig. 8 — Histology in liver and spleen sections from Farber disease mice receiving repeat injections of rhAC. Approximately 3-week-old Farber disease mice received once weekly i.p. injections of purified rhAC at doses of 1 mg/kg, 3 mg/kg and 10 mg/kg (n = 4–10/dose). Mice were euthanized when they lost > 10% body weight within a one week period. Livers (A) and spleens (B) were fixed in formalin, sectioned and subjected to H&E staining. “0” indicates Farber disease mice receiving once weekly injections of PBS. WT indicates age-matched wild-type mice. Representative sections are shown from mice in each dose group. Magnification = 20 ×.