Table 1.
Description of C. elegans – human orthologs. The Swiss-Prot accession numbers are given for the worm sequences and their human orthologs. TM: the number of transmembrane regions predicted using the consensus of nine different methods in the SFINX tool. Bootstrap support (%) is given for the inferred speciation node in the phylogenetic tree constructed using PHYLOWIN with PAM distances. Identity (%): sequence percentage identity from the Blastp output between the C. elegans gene and the nearest human ortholog. Four of the worm genes are predicted to have two splice variants (a and b). However, there are only small differences in the protein sequences between the two variants, except for R155.1. Splice variant R155.1b is predicted to have a truncation of more than one hundred amino acids in the N-terminus compared to R155.1a. The PF03062 domain (MBOAT) is still present in both splice variants. The protein sequence for R155.1a was used in the phylogenetic analysis.
| C. elegans orthologs | TM | Pfam-A domains | Human orthologs | Bootstrap support (%) | Identity (%) | Nearest human ortholog with putative function |
| C30H6.2 (Q9XVR4) | 6 | PF02535 (ZIP) | Q9H6T8, Q9NXC4, Q96NN4 | 57 | 50 | Q9H6T8: SLC39A4, involved in intestinal absorption of zinc. |
| T11F9.2a (Q8I4G0), T11F9.2b (Q22395) | 7 | PF02535 (ZIP) | Q15043, Q96SM9, Q9C0K1, Q96BB3 | 91 | 30 | Q9C0K1: BIGM103, involved in intracellular zinc retention and accumulation. |
| H13N06.5 (Q9XTQ7) | 9 | PF02535 (ZIP) | Q92504 | 98 | 52 | Transport of zinc out of ER2 and other intracellular stores. |
| T28F3.31 (Q9XUC4) | 7* | PF02535 (ZIP) | Q92504 | 79 | 38 | Transport of zinc out of ER2 and other intracellular stores. |
| T01D3.5 (Q9XVJ5) | 8 | PF02535 (ZIP) | Q9NUM3 | 99 | 38 | Function unknown. |
| F40F9.1a (Q8MQ56), F40F9.1b (Q8MQ55) | 7 | PF01027 (UPF0005) | Q9BWQ8, Q969X1 | 70 | 39 | Q9BWQ8: Lifeguard protein, protects cells from Fas-mediated cell death. |
| F40F9.2 (Q20241) | 7 | PF01027 (UPF0005) | Q9BWQ8, Q969X1 | 70 | 40 | Q9BWQ8: Lifeguard protein, protects cells from Fas-mediated cell death. |
| F08F1.7 (O17388) | 9* | PF02990 (EMP70) | Q99805 | 100 | 62 | Endosomal integral membrane protein. |
| ZK858.6a (Q94422) | 9 | PF02990 (EMP70) | Q92544 | 100 | 53 | Function unknown. |
| ZK858.6b (Q7YTF9) | 9* | |||||
| F14F3.3 (Q19468) | 9 | PF03062 (MBOAT) | Q96N66, Q99908 | 100 | 27 | Q99908: BB1 protein, malignant cell expression-enhanced gene. |
| R155.1a (O01925) | 8 | PF03062 (MBOAT) | Q92980 | 100 | 32 | Function unknown. |
| R155.1b (Q86DC4) | 4 | |||||
| C36B1.12 (Q93346) | 9* | PF04258 (Peptidase_A22B) | Q8TCT7, Q8TCT8, Q8IUH8 | 100 | 30 | Q8TCT7: Presenilin-like protein, may act as intra-membrane protease. |
| sft-4 (Q18864) | 7 | PF02077 (SURF4) | O15260 | 100 | 55 | Surfeit locus protein 4, probable ER2 integral membrane protein. |
| D2013.10 (O62126) | 6 | None | Q15055 | 98 | 53 | Function unknown. |
| T04A8.12 (Q22141) | 6 | None | Q9UHJ9 | 50 | 35 | FRAG1 (FGFR (fibroblast growth factor receptor) activating gene 1). |
| Y6B3B.10 (Q9XWE9) | 6 | PF03798 (LAG1) | P27544 | 99 | 37 | Function unknown. |
| ZK721.1 (Q9GYF0) | 10* | None | Q9NXL6, Q9Y357 | 97 | 34 | Function unknown. |
1 T28F3.3 was initially included because of strong similarity to Q92504; however, the phylogenetic analysis showed that it is probably an outparalog to the human gene.
2 ER = endoplasmic reticulum.
* predicted to have a N-terminal signal peptide.