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. 2016 Dec 2;31(5):1117–1122. doi: 10.1038/leu.2016.316

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Dynamics of RIPA after initiation of ibrutinib therapy in CLL patients. Consecutive measurements were available in 11 CLL patients and showed a marked decrease (median 17 U, range: 3–70 U vs median 9 U, range: 0–19 U, P=0.019) after a median period of 13 days of ibrutinib therapy.