Figure 10.

ZIKV infects the visual system in IFNR^−/− mouse. A–E, After intraocular inoculation of 4-week-old IFNR^−/− mice, ZIKV was identified at 4 dpi in visual system regions (A), including the optic tract (OT), lateral geniculate nucleus (LGN), superior colliculus (SC), and the suprachiasmatic nucleus (SCN). Contralateral to C, the other optic tract also showed ZIKV infection. F, In another IFNR^−/− mouse, intramuscular injection into the hind leg led to ZIKV infection of cells in and around the peripheral (per.) nerve innervating the leg. Scale bars: A, 200 μm; B, 60 μm; C, 40 μm; D, 60 μm; E, 40 μm; F, 30 μm.