Table 3. Reliability of HES data; Internal reliability: Intra-class correlation coefficient for each comorbidity; external reliability: Proportion of agreement for the diagnosis of the index cancer between the diagnostic fields of HES and the cancer registration data, by cancer and year of diagnosis.

	Larynx (2013)*			Larynx**
		95% CI			95% CI
Internal reliability	ICC	low	high	ICC	low	high
Myocardial infarction	0.27	0.17	0.37	0.27	0.24	0.30
Congestive heart failure	0.33	0.21	0.44	0.39	0.35	0.44
Peripheral vascular disease	0.26	0.16	0.35	0.34	0.31	0.38
Cerebrovascular disease	0.29	0.20	0.38	0.33	0.30	0.36
Dementia	0.56	0.32	0.80	0.62	0.53	0.72
Chronic pulmonary disease	0.38	0.31	0.45	0.54	0.52	0.56
Rheumatic disease	0.30	0.11	0.50	0.50	0.42	0.57
Peptic ulcer disease	0.09	0.01	0.18	0.19	0.15	0.22
Mild liver disease	0.31	0.20	0.43	0.39	0.34	0.44
Diabetes without chronic complication	0.38	0.28	0.48	0.52	0.48	0.56
Diabetes with chronic complication	0.18	-0.06	0.41	0.42	0.31	0.53
Hemiplegia or paraplegia	0.29	0.12	0.46	0.34	0.27	0.42
Renal disease	0.19	0.07	0.31	0.49	0.44	0.54
Any malignancy, including lymphoma and leukemia, except malignant neoplasm of skin	0.29	0.01	0.58	0.35	0.27	0.43
Moderate or severe liver disease	0.31	0.10	0.53	0.28	0.20	0.36
Metastatic solid tumor	0.00	0.00	0.00	0.00	0.00	0.00
AIDS/HIV	0.25	-0.88	1.39	0.43	-0.10	0.96
Morbid obesity	0.18	0.06	0.31	0.30	0.24	0.36
External reliability
Proportion agreement HES/ONS	86.31	84.62	87.87	86.26	85.72	86.79

*Larynx 2013-cohort, N = 1,789

** All cohorts, N = 16,112