Table 2. Changes in BMI SDS and WC during 1.5 years of treatment.
| 3 months Estimate (95% CI) |
6 months Estimate (95% CI) |
9 months Estimate (95% CI) |
12 months Estimate (95% CI) |
15 months Estimate (95% CI) |
18 months Estimate (95% CI) |
|
|---|---|---|---|---|---|---|
| Δ BMI SDS | ||||||
| Boys | −0.23* | −0.30* | −0.32* | −0.34* | −0.35* | −0.38* |
| (−0.20 to −0.26) | (−0.26 to −0.33) | (−0.28 to −0.37) | (−0.29 to −0.39) | (−0.29 to −0.41) | (−0.30 to −0.45) | |
| Girls | −0.18* | −0.24* | −0.25* | −0.22* | −0.20* | −0.18* |
| (−0.16 to −0.20) | (−0.22 to −0.27) | (−0.22 to −0.28) | (−0.18 to −0.26) | (−0.14 to −0.25) | (−0.12 to −0.24) | |
| Δ WC (cm) | ||||||
| Boys | −2.7* | −3.4* | −3.5* | −3.6* | −3.7* | −3.8* |
| (−1.4 to −2.0) | (−2.9 to −3.9) | (−2.9 to −4.1) | (−2.8 to −4.3) | (−2.8 to −4.6) | (−2.7 to −4.9) | |
| Girls | −3.4* | −4.2* | −4.3* | −4.4* | −4.6* | −5.1* |
| (−3.0 to −3.8) | (−3.7 to −4.6) | (−3.7 to −4.9) | (−3.7 to −5.1) | (−3.7 to −5.5) | (−4.0 to −6.2) | |
| ΔBMI SDS groups | ||||||
| Boys | (n = 318) | (n = 375) | (n = 334) | (n = 283) | (n = 208) | (n = 134) |
| < −0.50 | 12.3% | 25.1% | 27.0% | 29.0% | 33.2% | 32.1% |
| < −0.25 to −0.50 | 23.9% | 20.8% | 21.0% | 23.7% | 19.2% | 18.7% |
| < 0.00 to −0.25 | 39.6% | 32.0% | 30.5% | 26.1% | 22.6% | 23.1% |
| ≥ 0.00 | 24.2% | 22.1% | 21.5% | 21.2% | 25.0% | 26.1% |
| Girls | (n = 397) | (n = 453) | (n = 420) | (n = 352) | (n = 264) | (n = 178) |
| < −0.50 | 4.5% | 15.0% | 20.7% | 23.6% | 26.9% | 29.2% |
| < −0.25 to −0.50 | 20.2% | 23.2% | 23.1% | 21.0% | 18.0% | 15.2% |
| < 0.00 to −0.25 | 53.1% | 41.0% | 35.5% | 30.1% | 32.0% | 29.2% |
| ≥ 0.00 | 22.2% | 20.8% | 20.7% | 25.3% | 23.1% | 26.4% |
BMI, body mass index; SDS, standard deviation score; WC, waist circumference (age-adjusted); CI, confidence interval; n, number of boys/girls in the analyses.
* Statistically significant change in BMI SDS as a function of time (p<0.0001). Changes in BMI SDS and age-adjusted WC were analyzed using linear mixed models. Cumulative percentages with BMI SDS reductions were calculated in the children and adolescents who were eligible at each time point.