Figure 5.

Responder analysis of clinically relevant change from baseline in breathlessness assessed by (A) TDI focal score, and health status assessed by either (B) SGRQ total score or (C) CAT score (ITT population).

Notes: TDI responder defined as a ≥1-unit improvement from baseline; SGRQ total score responder defined as a ≥4-unit reduction from baseline; and CAT score defined as a ≥2-unit reduction from baseline.

Abbreviations: CAT, COPD Assessment Test; CI, confidence interval; ITT, intent-to-treat; OR, odds ratio; SGRQ, St George’s Respiratory Questionnaire; TDI, Transition Dyspnea Index; TIO, tiotropium; UMEC, umeclidinium; VI, vilanterol.