Table 3.
Patient-reported outcomes (ITT population)
| Outcome measure | UMEC/VI (N=247) |
TIO (N=247) |
|---|---|---|
| TDI score | ||
| Day 28 | ||
| na | 235 | 238 |
| LS mean (SE) | 1.8 (0.16) | 1.3 (0.16) |
| Difference (95% CI) | 0.5 (0.0–0.9)* | |
| Day 56 | ||
| na | 232 | 235 |
| LS mean (SE) | 1.9 (0.15) | 1.8 (0.15) |
| Difference (95% CI) | 0.1 (−0.3–0.5) | |
| Day 84 | ||
| na | 226 | 233 |
| LS mean (SE) | 2.3 (0.16) | 1.9 (0.16) |
| Difference (95% CI) | 0.4 (−0.1–0.8) | |
| SGRQ total score | ||
| Day 28 | ||
| na | 232 | 237 |
| LS mean change (SE) | −3.23 (0.59) | −2.67 (0.59) |
| Difference (95% CI) | −0.55 (−2.20–1.09) | |
| Day 84 | ||
| na | 225 | 232 |
| LS mean change (SE) | −4.41 (0.68) | −4.21 (0.67) |
| Difference (95% CI) | −0.20 (−2.09–1.68) | |
| CAT score | ||
| Day 28 | ||
| na | 242 | 240 |
| LS mean change (SE) | −1.56 (0.31) | −1.17 (0.31) |
| Difference (95% CI) | −0.39 (−1.25–0.48) | |
| Day 84 | ||
| na | 233 | 235 |
| LS mean change (SE) | −2.10 (0.36) | −1.84 (0.35) |
| Difference (95% CI) | −0.26 (−1.25–0.72) |
Notes:
*
P<0.05.
a
Number of subjects with analyzable data at the current time point.
Abbreviations: CAT, COPD Assessment Test; CI, confidence interval; ITT, intent-to-treat; LS, least squares; SE, standard error; SGRQ, St George’s Respiratory Questionnaire; TDI, Transition Dyspnea Index; TIO, tiotropium; UMEC, umeclidinium; VI, vilanterol.