Fig 9. Treatment with H4C4 also blocked coalescence of melanoma cells exiting fresh melanoma tissue in the 3D Matrigel model.

A. Only one potential coalescence event was observed in the treated preparation (white arrow, 48 hr), but the bridge that formed did not fully did not pull the smaller into the larger aggregate and the cells separated at 52 hr (white arrow, 52 hr). B. Coalescence in the absence of mAb. Coalesced cells are color-coded blue in panel B.