Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Feb 27;10:1237–1246. doi: 10.2147/OTT.S128819

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Luan et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

miR-204-5p inhibits melanoma growth in vivo and increases sensitivity of melanoma cells to chemotherapy. (A) Tumor formation in nude mice and the excision tumor of A375 xenografts. (B) Difference in tumor volume between the NC group and the miR-204-5p group. (C) The tumor weight of excision tumor. (D) PCR identified miR-204-5p expression changes. (E) Western blots identified MMP9 and BCL2 protein expression changes. (F) A dose-dependent 5-FU and DDP treatment was conducted on miR-204-5p mimic- or NC-transfected melanoma cells. The proliferative ability of A375 cells was measured by CCK-8 assay. *P<0.05, **P<0.01.

Abbreviations: NC, negative control; 5-FU, 5-fluorouracil; CCK-8, cell-counting kit-8; PCR, polymerase chain reaction; MMP9, matrix metalloproteinases-9; BCL2, B-cell lymphoma-2; DDP, cisplatin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.