Table 4.
Treatment attribute | DLQI ≤10, n=166, OR (95% CI) | DLQI >10, n=126, OR (95% CI) | Biologic therapy experience, n=75, OR (95% CI) | Biologic therapy naïve, n=217, OR (95% CI) |
---|---|---|---|---|
BSA (per palm area) | 0.90 (0.88–0.93)a | 0.97 (0.95–1.00) | 0.97 (0.94–1.00) | 0.90 (0.88–0.92)a |
Increased risk of diarrhea or nausea (per 5% increase) | 0.84 (0.79–0.90)a | 0.88 (0.82–0.94)a | 1.01 (0.93–1.09) | 0.79 (0.75–0.85)a |
Increased risk of melanoma or nonmelanoma skin cancer (per 5% increased 10-year risk) | 0.43 (0.35–0.53)a | 0.45 (0.36–0.56)a | 0.57 (0.44–0.74)a | 0.38 (0.32–0.46)a |
Increased risk of tuberculosis (per 5% increased 10-year risk) | 0.73 (0.66–0.80)a | 0.75 (0.67–0.83)a | 0.85 (0.75–0.97)a | 0.66 (0.60–0.72)a |
Increased risk of serious infection (per 5% increased 10-year risk) | 0.70 (0.67–0.72)a | 0.79 (0.76–0.81)a | 0.87 (0.85–0.90)a | 0.70 (0.68–0.72)a |
Twice-daily tablet (relative to once-weekly tablet) | 0.74 (0.60–0.91)a | 0.75 (0.61–0.93)a | 0.79 (0.61–1.02) | 0.71 (0.59–0.85)a |
Weekly injection (relative to once-weekly tablet) | 0.48 (0.39–0.61)a | 0.72 (0.57–0.90)a | 0.84 (0.63–1.11) | 0.43 (0.35–0.53)a |
Fortnightly injection (relative to once-weekly tablet) | 0.49 (0.40–0.60)a | 0.86 (0.70–1.06) | 0.78 (0.60–1.02) | 0.57 (0.48–0.69)a |
Note:
Attributes significant at the <5% level.
Abbreviations: BSA, body surface area; CI, confidence interval; DCE, discrete choice experiment; DLQI, Dermatology Life Quality Index; OR, odds ratio.