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. 2004 Dec;78(24):13708–13716. doi: 10.1128/JVI.78.24.13708-13716.2004

FIG. 5.

FIG. 5.

Molecular model of the interaction between the NS2B core segment and the NS3 protease. The model was generated by Deepview Swiss-Pdbviewer. (A) NS2B(H) (residues 56 to 93) mapped onto the X-ray crystal structure of NS3. The surface of NS3pro is shown in blue, and NS2B(H) is shown as a ribbon in yellow. The location of Trp62 at the N terminus of NS2B(H) is shown. (B) Interaction of residues Leu75, Ile77, and Ile79 with the hydrophobic pocket of NS3. The surface of NS3 is colored by the residue type (yellow, polar; blue, basic; red, acidic; white, nonpolar); the NS2B segment is shown as a yellow stick with the side chains of Leu75, Ile77, and Ile79 in grey. (C) Association of the Trp62 residue (red) of NS2B(H) (yellow ribbon) with the N-terminal proline cluster of NS3 (side chains in green and NS3 in blue).