Table 3.

Biological process analysis of the genetic interaction network associated with carfilzomib resistance in KMS-11 cell line in terms of GO

GO ID	Biological process	Observed gene count	FDR
GO.0009605	Response to external stimulus	38	3.22E-12
GO.0002376	Immune system process	34	1.27E-08
GO.0006955	Immune response	26	3.71E-07
GO.0009991	Response to extracellular stimulus	16	8.57E-07
GO.0009628	Response to abiotic stimulus	23	1.42E-06
GO.0060548	Negative regulation of cell death	21	1.42E-06
GO.0031667	Response to nutrient levels	15	1.79E-06
GO.0006950	Response to stress	40	2.12E-06
GO.0051716	Cellular response to stimulus	54	2.41E-06
GO.0007173	Epidermal growth factor receptor signaling pathway	11	5.14E-06
GO.0010941	Regulation of cell death	25	5.37E-06
GO.0043066	Negative regulation of apoptotic process	19	6.83E-06
GO.0000422	Mitophagy	6	1.42E-05
GO.0001934	Positive regulation of protein phosphorylation	18	1.42E-05
GO.0008284	Positive regulation of cell proliferation	18	1.42E-05
GO.0033554	Cellular response to stress	25	2.09E-05
GO.0042981	Regulation of apoptotic process	23	2.09E-05
GO.0044710	Single-organism metabolic process	42	2.09E-05
GO.0050896	Response to stimulus	56	2.38E-05
GO.0016236	Macroautophagy	7	3.06E-05
GO.0043410	Positive regulation of MAPK cascade	13	3.62E-05
GO.0016049	Cell growth	8	3.78E-05
GO.0044712	Single-organism catabolic process	18	3.78E-05
GO.0031668	Cellular response to extracellular stimulus	10	4.04E-05
GO.0030334	Regulation of cell migration	15	4.43E-05
GO.0044804	Nucleophagy	5	4.43E-05

Abbreviations: FDR, false discovery rate; GO, Gene Ontology; MAPK, mitogen-activated protein kinase.