Table 3.
Summary of RRs with 95% CIs of adverse events
| Adverse events | OFC vs fluoxetine
|
OFC vs olanzapine
|
||
|---|---|---|---|---|
| RR (95% CI) | P-value | RR (95% CI) | P-value | |
| Weight increase | 2.53 (0.86–7.39) | 0.090 | 0.70 (0.41–1.20) | 0.197 |
| Increased appetite | 2.50 (0.92–6.77) | 0.072 | 0.66 (0.38–1.15) | 0.142 |
| Dry mouth | 1.58 (0.64–3.90) | 0.318 | 0.60 (0.33–1.11) | 0.105 |
| Somnolence | 1.97 (1.09–3.56) | 0.026 | 0.70 (0.34–1.46) | 0.346 |
| Fatigue | 1.57 (1.14–2.16) | 0.006 | 0.91 (0.69–1.19) | 0.482 |
| Headache | 0.53 (0.28–1.01) | 0.052 | 0.69 (0.35–1.37) | 0.294 |
| Peripheral edema | 10.16 (4.61–22.38) | <0.001 | 1.02 (0.46–2.24) | 0.968 |
| Tremor | 1.66 (0.91–3.01) | 0.096 | 1.70 (1.18–2.43) | 0.004 |
| Dizziness | 0.56 (0.18–1.75) | 0.319 | 0.66 (0.22–1.99) | 0.458 |
| Sedation | 3.11 (1.60–6.03) | 0.001 | 0.80 (0.52–1.22) | 0.297 |
| Hypersomnia | 3.57 (1.92–6.63) | <0.001 | 0.82 (0.57–1.20) | 0.307 |
Abbreviations: CI, confidence interval; OFC, olanzapine/fluoxetine combination; RR, risk ratio.