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Defect in actin depolymerization (A–L).
Notes: A549 cells were incubated with 500 nM latrunculin A (D–F, J–L) or solvent (A–C, G–I) for 30 min prior to fixing and Alexa Fluor 488-phalloidin and Hoechst 33342 staining to visualize actin and nuclei, respectively. Cells were analyzed by confocal microscopy.
Abbreviations: Abr, Abraxane; PTX, paclitaxel.
