Table 2.
Pre-Post Changes (± SEM) in Day 1 Affect and Anxiety and Day 2 Cortisol
| Measure/Condition | Pre | Post |
|---|---|---|
| Day 1 Positive Affect (PANAS) | ||
| Stress | ||
| Carriers (n = 25) | 24.37 (1.50)*,β | 22.61 (1.59)*,β |
| Non-carriers (n = 31) | 29.59 (1.22)* | 26.94 (1.30)* |
| No Stress | ||
| Carriers (n = 33) | 29.41 (1.17)β | 26.64 (1.25)β |
| Non-carriers (n = 23) | 29.61 (1.43) | 28.67 (1.53) |
| Day 1 Negative Affect (PANAS) | ||
| Stress | ||
| Carriers (n = 25) | 13.87 (0.90) | 13.54 (0.99) |
| Non-carriers (n = 31) | 13.77 (0.74) | 14.04 (0.81) |
| No Stress | ||
| Carriers (n = 33) | 14.09 (0.71) | 13.81 (0.77) |
| Non-carriers (n = 23) | 14.22 (0.86) | 14.34 (0.95) |
| Day 1 Anxiety (SAI) | ||
| Stress | ||
| Carriers (n = 25) | 34.42 (2.24) | 40.02 (2.31) |
| Non-carriers (n = 31) | 36.43 (1.83) | 38.86 (1.89) |
| No Stress | ||
| Carriers (n = 33) | 35.57 (1.76) | 36.21 (1.81) |
| Non-carriers (n = 23) | 34.20 (2.15) | 37.92 (2.21) |
| Day 2 Salivary Cortisol (nmol/l) | ||
| Stress | ||
| Carriers (n = 25) | 5.81 (0.66) | 6.01 (0.57) |
| Non-carriers (n = 31) | 5.26 (0.54) | 5.44 (0.47) |
| No Stress | ||
| Carriers (n = 33) | 4.78 (0.52) | 5.57 (0.45) |
| Non-carriers (n = 23) | 5.72 (0.64) | 5.83 (0.55) |
Note: the data for rs1360780 are presented as a representative example of all FKBP5 SNP effects. PANAS = Positive and Negative Affect Scale; SAI = State Anxiety Inventory;
*
main effect of stress p < 0.05 relative to no stress;
β
main effect of genotype p < 0.05 relative to non-carriers.