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. 2016 Dec 7;123(6):1061–1070. doi: 10.1002/cncr.30437

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© 2016 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Patient risk and overall survival as assessed by the MET FISH status. (A) Cox proportional hazards model evaluation of FISH classification with respect to overall survival. HRs along with 95% CIs are depicted for MET‐amplified tumors versus unamplified tumors as characterized by 3 separate criteria. (B‐D) Kaplan‐Meier curves depicting the overall survival of subjects with MET‐amplified tumors versus unamplified tumors as characterized by (B) the MET/CEP7 ratio, (C) the average gene copy number, and (D) the percentage of tumor cells containing at least 15 copies of MET. CEP7 indicates centromere enumeration probe for chromosome 7; CI, confidence interval; FISH, fluorescence in situ hybridization; HR, hazard ratio.